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biology 0610printed 136 · PDF 136
328 pagesrevision 46933
printed 136 · PDF 136
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Antibiotic peptides occur naturally on the surface of human skin. One of these peptides, called
LL-37, and three other similar synthetic peptides were investigated to assess both their
antibiotic properties and effect on human cells,
The graphs show the antibiotic effect of the peptides against two microbes, S. aureus and C.
albicans. The technique involves measuring the inhibition of growth of the microbes.
S. aureus C. albicans Key for
10 - 10 - peptides:
= SLLG
5 84 a OGKE
= 7
3 2 “f aFKR
: Fee
= 5 64 rf @LL-37
| c a“ a
sé | as
e= 44 a
s¢ fi. 30?
53 7
BS 24 Lee
a7
-$ +—+ +
5 20 40 100
Peptide concentration / mol dm”
{Source: T Sigurdardottir, et al., (2006), Antimicrobial Agents and Chemotherapy, 50 (9), pages 2983-2989}
(a) Describe the effect of the FKR on C. albicans.
(2)
(b) Compare the effects of the peptide LLG on S. aureus and C. albicans.
(2)
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