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biology 0610printed 139 · PDF 139
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Aitchison College Academic
Antibiotic peptides occur naturally on the surface of human skin. One of these peptides, called
LL-37, and three other similar synthetic peptides were investigated to assess both their
antibiotic properties and effect on human cells.
The graphs show the antibiotic effect of the peptides against two microbes, S. aureus and C.
albicans. The technique involves measuring the inhibition of growth of the microbes.
Amount of inhibition /
(b)
S. aureus C. albicans Key for
10 10 ~ peptides:
BLLG
8 - Fis OGKE
2 aa a FKR
c oars
s 64 ey e@LL-37
4 OO cg
= 4 a
2 fae
a yh
24 4°
a7
tty as ya DUE a , T ,
5 20 40 100 5 20 40 100
Peptide concentration / umol dm*
{Source: T Sigurdardottir, et al., (2006), Antimicrobial Agents and Chemotherapy, 50 (9), pages 2983-2989}
(2)
Compare the effects of the peptide LLG on S. aureus and C. albicans.
No effect on S. aureus and inhibition on C.
Albicans
i sppsi had oppuigcacsa oy epyansfabed dupe nvepyyeoivarbnasad oy jay obeansnbees puSang ouaw vay vepphassatasessuneye ey oben oan ®
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